Pimaricin CAS NO.7681-93-8

ⅡSPECIFICATION OF PRODUCT

The specification of WeiRi-Brand Natamycin is listed as the table below:

Program Specification

Appearance Cream-colored to slightly yellow powder

Content  (%)     ≥95

pH       5.0-7.5

Moisture(%) ≤6-9(vacuum 666.5Pa,60℃,dry by P2O5)

AS,GT-3(mg/kg)           ≤1

Heavy Metals(Pb)(%)           ≤0.002

Count of Colony(cfu/g)   ≤100

 

Ⅲ HAZARD IDENTIFICATION

Personal hazard: strong irritating to eyes

Environment hazard: None

 

Ⅳ FIRST AID MEASURES

Eye contact: Severe irritation,redness,tears.

           Immediately wash out with plenty of water

           Seek medical attention

 

Ⅴ PHYSICAL PROPERTIES

State:     Power solid

Solubility: The solubility of natamycin is very low in water,and a little higher in ethanol.Natamycin could dissolve in low concentration of HCL,glacial acetic acid and dimethysulfoxide etc.,but is insoluble in most organic solvents.The solubility iof natamycin in water is about 30-100mg/l at room tempreature.It will increases when pH≥9 or 3,which will decrease the antifungal activity.

 

Ⅵ STABILITY

Tempreature:Natamycin is stable at room tempreature,more stable under dry condition.The desiccated natamycin could endre 100℃ in short-time.But the activity will be decreased when it kept for more than 24 hours at ≥50℃.

pH value:Natamycin shows the highest activity at pH5-7.The activity will decrease 8%-10% at pH3-5,and decrease about 30% when Ph＜3 or ＞9.

Light:Natamycin in lpowder or solution is sensitive to UV or ray,which will cause the lose of activity.So,the direct sunlight exposure should be avoided.

Oxidants:Natamycin is sensitive to oxidants,such as peroxide,chlorine dioxide,and bleaching powder etc,which will decrease the activity if natamycin.The use of antioxidants,e.g.vitamin C,could prevent it.

Heavy Metals:The Pb,Hg,Fe,and Ni etc,could affect the stability of natamycin,So,natamycin or its solution should be stored in container made of glass,plastic or stainless steel.The EDTA could also be mixed with it to prevent the lose of activity

 

Ⅶ ANTIFUNGAL MECHANISM

The antifungal mechanism of natamycin is:the natamycin could bind the sterols in the cell membrane,and cause the distortion and malfunction of the membrane,wherely essential metabolites leak out and the cell dead.However,natamycin could not inhibit the growth of bacteria because no has no sterols exist in the bacterial cell wall and the cellmembrane.

 

Ⅷ PACKING AND STORAGE

Packing: 250g/bottle,500g/bottle with self-sealed screw-caps,10 bottles/case,20 bottles/case, or packed at customer´s request.

Storage: WeiRi-brand natamycin is stable for 24 months from the date of

manufacture when it is stored in dry conditions, away from direct sunlight and between 2℃and 15℃.