Nisin CAS NO.1414-45-5

We are one of the largest manufacturers in China,and we have14 years rich experiences in this product.

Nisin is a kind of natural food preservatives,can be widely used in food,dairy,cheese,canned food,yoghurt,meat,sausage and the other kinds of food.

The use of Nisin, as a food preservative, can greatly decrease the required temperature and shorten the time in food heat processing, which could not only improve the nutritional value, appearance, flavor and texture of foods, significantly prolong the shelf-life, but also save energy greatly and lower the product cost. Now, Nisin has been used in a wide range of processed foods, e.g. cured meat, dairy products, plant protein foods, canned foods, and heat-treated/air-tightly packed foods etc, it can also be used in the area of cosmetics, medicines and health products. 

l  Technical Data of the Product

Product Name: WeiRi-Brand Nisin 

Molecular Formula:  C143H228O37N42S7

Molecular Weight: 3348

Product code:  China： 17.019

INS ： 234 

CAS ： 1414-45-5 

l  Specification of Product 

Program                           Specification 

Appearance                       Off-white powder

Content (IU/mg)                   ≥ 1000 

Moisture(%)                      ≤ 3 

Heavy Metals (Pb) (mg/kg)          ≤ 0.001  ≤ 10 

As(%)                           ≤ 0.0001 

NaCl (%)                         ≥ 50 

Count of Colony (cuf/g)             ≤ 10 

E. coli. (MPN/100g)                ≤ 30 

Salmonellae spp.                   Absent in 25g

l  Stability

Nisin is most stable under acid conditions. It can keep the activity after the treatment at 121℃ for 30mins at pH2; 47% of the activity remained after the treatment in 110℃ for 30mins in nonfat milk in pH6.5; But the activity lost rapidly in 30 minutes at 63℃ in pH 11.

l  Solubility 

Nisin can be dissolved in aqueous solution, but is insoluble in non-polar solvents. The solubility decreases with the increase of pH, and it increases with the rise of temperature.

l  Anti-microbial Properties 

Nisin possesses highly of inhibiting activities to Gram-positive bacteria，particularly to spore- forming bacteria. It does not influence Gram-negative bacteria, yeasts and moulds generally. But under some circumstances (such as freezing, heating, low pH and adding of EDTA), Nisin can inhibit some Gram-negative bacteria such as Salmonella spp, Shigella spp, Klebsiell spp Escherichia coli etc.

l  Direction of Usage

About 5% aqueous solution is prepared firstly with cold boiled water or distilled water (best with diluted acid solution), then instantly put it into food and stirs well. Or put it directly into food and stirs well.

 Recommended Dosage 

The general dosage is 0.05g/kg-0.1g/kg. The detail dosage of Nisin depends on products, material quality, process, shelf life and storage conditions, etc. 

Packing and Storage

A. Packing: 

WeiRi-brand Nisin is supplied in 500g/bottle, 1000 g/bottle with self-sealed screw-caps, 10 bottles/case 20 bottles/case, or packed at customer′s request.

B. Storage: 

WeiRi-brand Nisin is stable for 24 months from the date of manufacture when it is stored in dry conditions, away from direct sunlight and below 10℃.